老马 发表于 2013-12-13 12:14
罗氏的Brain Shuttle技术
http://www.roche.com/research_and_development/what_we_are_working_on/resear ...
http://www.reuters.com/article/2 ... USBREA070ZY20140108
(Reuters) - Swiss drugmaker Roche has found an efficient way for complex antibody drugs to reach and penetrate the brain, raising the possibility of more effective treatments for diseases such as Alzheimer's.
The innovative brain shuttle technology, which has so far been tested in mice, can cross the blood-brain barrier that has been a key obstacle for researchers working on neurological drugs because it acts as a seal against large molecules such as antibodies.
Alzheimer's is a fatal brain-wasting disease that affects 44 million people worldwide, with the number set to triple by 2050, campaign group Alzheimer's Disease International says.
Although there is still no treatment that can effectively modify the disease or slow its progression, a number of companies - including Roche, Eli Lilly, Merck & Co and Johnson & Johnson - are pursuing a variety of approaches to get to the root cause.
It is proving an uphill battle. Over the past 15 years more than 100 experimental Alzheimer's drugs have failed in tests. Industry analysts believe that the prize for a truly effective drug could be a market worth $10 billion in annual sales.
Roche's new technology works by hijacking a natural transport mechanism called receptor-mediated transcytosis, which is normally used by the body to transfer proteins inside the brain.
"We have basically designed this module, called shuttle, that binds to this transport mechanism and shuttles a cargo inside the brain," Luca Santarelli, Roche's head of neuroscience, ophthalmology and rare diseases, said in a telephone interview.
ANTIBODY BOOST
Results of a study published in the journal Neuron on Wednesday found the technology helped to increase the concentration of antibodies in the brains of mice, reducing the amount of amyloid plaque, which is a hallmark of Alzheimer's.
Roche tested a precursor of its experimental Alzheimer's drug gantenerumab in the pre-clinical trials. The amount of antibody that penetrated the brain increased more than fiftyfold.
Santarelli said that the brain shuttle technology is not limited to the memory-robbing disease and could be applied to other neurodegenerative disorders such as Huntington's disease. The drugmaker is in the process of evaluating which therapeutic targets and diseases to prioritize.
Roche has struck a deal with U.S. biotech firm Isis to develop treatments for Huntington's and aims to engineer a shuttle to increase penetration of drugs into the brain. It is also working on a program with Irish company Prothena in Parkinson's disease.
Santarelli said that all projects are still in pre-clinical testing and the company needs to undertake a few more steps before it can begin clinical trials.
Turning to Roche's Alzheimer's pipeline, he said that its Phase III trial of gantenerumab in patients who have yet to develop dementia is on track, with results expected in the first half of 2016.
Roche has two other drugs in clinical testing, including crenezumab, which has been chosen for a U.S. government-backed trial in a group of Colombians with a genetic mutation that leads to Alzheimer's in their forties.
|
母亲奥希替尼耐药 求耐药后续方案
母亲肺腺癌晚期服用奥希替尼两年耐药，做了胸膜穿刺取组织基因检测，求后续的治疗方案
今天搜索发现这个【加科思JAB-30355
前几天老爸的基因检测报告出来了，很沮丧，没有药，只有tp53突变，今天就搜索了下这个
术前2期，术后3A期肺鳞癌错过新辅助
2023年11月第一次肺炎抗炎治疗半月，
2024年2月年后又一次肺炎治疗后于3月初肺科医院
【求助】EGFR+RB1+TP53脑膜转移，不
治疗经过和背景：
2022年：
父亲2022年10月底确诊肺腺癌，初诊就有骨（肩胛骨，腰椎
转余药可瑞达k药和伦伐替尼还有金克
可瑞达k药在冰箱，伦伐正版的乐卫码和槐耳颗粒还有三盒多多纳非尼，微信p8xx99
显身卡
