发给老马备查:
1 [2 L/ {" x+ u* c5 ~# V滴水察海(69304838) 15:23:238 [2 L; {( F: @
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱1 }& Q0 ~# P8 Y4 B7 _( T, q- I, r
吉非替尼和S-1连用的依据) j! \$ ^, P8 f4 ], Z
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
/ n# V& b, J8 B% }$ ` J$ F+ i* Q是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
! C p* G. I- I这样是不是推理出,耐药后,可以用S-1和培美了?, a' k7 X' o+ n- ^3 o+ n# q
结论:- D& k, B. A* \4 G" R# |* g
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |