发给老马备查:! y* ~. ~9 Y. X
滴水察海(69304838) 15:23:230 }2 v! |9 @1 ?
老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
& l9 I& ]; B( @1 n, P0 F+ J+ ^/ }吉非替尼和S-1连用的依据" G5 U; S7 L& i$ }# Y+ ^
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.- x" q0 r" Q" x: J% U# D7 h- g
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
: p# K, t% o" ~' k M4 S这样是不是推理出,耐药后,可以用S-1和培美了?
; d p- P, ~ g( k) \5 x结论:- }, o! U/ V1 @% H3 D1 T
如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |