发给老马备查:
% n5 |7 `$ |7 q, a; G滴水察海(69304838) 15:23:23
" M, W" l/ N" p) s2 p6 P$ i老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱* \# e: X, L& e* o" k5 Z) c3 Q
吉非替尼和S-1连用的依据3 n1 z% i& M( n- n
Gefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.! l0 Y6 Q8 u% Z# J$ P
是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
2 R8 K2 P9 L/ Z3 r% t" C: j这样是不是推理出,耐药后,可以用S-1和培美了?
0 Y* [) C5 V( ]. @) {* h4 _结论:
0 e% B$ i( q$ \0 H( G, ~如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |