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非小细胞肺癌(NSCLC)的化疗宝典

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1749005 281 老马 发表于 2012-5-19 12:38:14 | 置顶 |
老马  博士一年级 发表于 2014-1-5 12:51:06 | 显示全部楼层 来自: 浙江温州
Supplements—for better or worse?
Chemotherapy-induced peripheral neuropathy is a very common and debilitating adverse effect of cancer therapy, which can often lead to treatment discontinuation. There are no good treatments or ways to prevent this adverse effect. However, preclinical studies and a phase II trial showed that the natural compound acetyl-L-carnitine (ALC) has efficacy, with improvements noted in some
patients. This finding prompted Dawn Hershman and colleagues to conduct a prospective, randomized, placebo-controlled trial in women undergoing taxane-based adjuvant therapy for early
stage breast cancer.
In total, 409 patients were randomly assigned to receive ALC or placebo. The primary outcome of the trial was patient-reported symptoms of peripheral neuropathy. Unfortunately, as Hershman
summarizes, the results of the trial were negative. “Not only did we not find a protective effect of ALC at 12 weeks, we found that by 24 weeks there was a statistically significant worsening of
peripheral neuropathy in the patients on trials that were randomized to the ALC supplement.”
To the authors’ knowledge, this is the first study to show a detrimental effect of a supplement on the development of taxane-related peripheral neuropathy. As the use of complementary medicine is widespread, the study researchers caution that patients should be discouraged from using ALC
and other nutritional supplements that do not have proven efficacy. Hershman comments on future plans for this area: “some studies are ongoing to see if ALC is more beneficial for treatment as opposed to prevention. We will investigate other approaches for treating and preventing
this terrible side effect.”
Lisa Hutchinson
Original article Hershman, D. L. et al. Randomized double-
blind placebo-controlled trial of acetyl-l-carnitine for
the prevention of taxane-induced neuropathy in women
undergoing adjuvant breast cancer therapy. J. Clin. Oncol.
doi:10.1200/JCO.2012.44.8738
个人公众号:treeofhope

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小小的解百纳  高中一年级 发表于 2014-2-27 15:47:48 | 显示全部楼层 来自: 山东青岛
高手在民间。虽然害怕化疗,但是还是要学习 再学习。。。。
懂得一切 原谅一切

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幸福安康  小学六年级 发表于 2014-7-31 13:15:48 | 显示全部楼层 来自: 云南昆明
除了感谢还是感谢,马哥辛苦。积极学习中

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BQQ0404  高中二年级 发表于 2014-8-1 11:15:41 | 显示全部楼层 来自: 江苏南京
谢谢,学习了

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期待奇迹出现  小学五年级 发表于 2014-8-3 21:46:51 | 显示全部楼层 来自: 安徽马鞍山
谢谢这么好的资料,辛苦了

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vicky_tdl  初中一年级 发表于 2014-8-24 08:46:14 来自手机 | 显示全部楼层 来自: 江苏南京
努力学习中,谢谢老马。

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雪中精灵  初中一年级 发表于 2014-8-31 19:18:03 | 显示全部楼层 来自: 湖南
任何事情都要有备才能无患,以后请大家多多帮忙、互帮互助!

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破而后立  高中三年级 发表于 2014-9-1 18:41:27 | 显示全部楼层 来自: 广东珠海
感谢分享。

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tidings  初中二年级 发表于 2014-9-5 20:49:03 | 显示全部楼层 来自: 中国
老马一出手,就知有没有。
anywn  小学六年级 发表于 2014-9-9 22:11:22 | 显示全部楼层 来自: 山东威海
又挖到宝了

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